SL OMFX

  Answer : Fibrous dysplasia Skeletal anomaly which normal bone is replaced and distorted by poorly organized and inadequately mineralized immature bone and fibrous tissue Single bone – Monostotic (Craniofacial fibrous dysplasia – monostotic variant) Multiple bone – Polyostotic fibrous dysplasia Multiple bone + multiple endocrine abnormalities – Mc cune Albrights syndrome  7 % of all benign tumours Disorder of growing bone in children and adolescents A missense mutation in GNAS gene – overexpression of cAMP – changes in properties of osteoprogenitor cells Milder forms affect few bones – craniofacial and femur  Maxilla > mandible Clinical –  Painless swelling of jawbones, Facial asymmetry First 2 decades of life Displacement of teeth, malocclusion  Paranasal sinuses, orbits and foramina of the base of the skull can produce – Visual loss, hearing loss, headache, nasal obstruction Radiology – Classic lesions show ground glass appearance  Table 4 Histopath...