SL OMFX

  Answer : Adenoid cystic Carcinoma Salivary gland malignancy slow-growing relentless salivary gland malignancy composed of epithelial and myoepithelial neoplastic cells that form various patterns F : M = 1.5 : 1 4.4 % of all salivary gland tumours Median patient age 57 years  Swiss cheese appearance MYB translocation 3 types – Cribriform, Tubular, Solid Perineural and intraneural invasion – 30 % Comedo type necrosis in solid type – ACC – Resembles Basal Cell Ca Grade I, II, III 5 year survival drastic difference but 15-year survival almost equal Histopathology Cribriform Nests of tumour cell interrupted by  Sharply punched out spaces filled with basophilic matrix Small Angulated hyperchromatic nuclei Perineural invasion Tubular Bi layered tubules with true lamina Scant cytoplasm Small Angulated hyperchromatic nuclei Solid Sheets of tumour cell Without lumen May consist of epithelial-myoepithelial elements Immunohistochemistry – CD 117 inner epithelial cells, P63, SMA- ...

  Answer : Fibrous dysplasia Skeletal anomaly which normal bone is replaced and distorted by poorly organized and inadequately mineralized immature bone and fibrous tissue Single bone – Monostotic (Craniofacial fibrous dysplasia – monostotic variant) Multiple bone – Polyostotic fibrous dysplasia Multiple bone + multiple endocrine abnormalities – Mc cune Albrights syndrome  7 % of all benign tumours Disorder of growing bone in children and adolescents A missense mutation in GNAS gene – overexpression of cAMP – changes in properties of osteoprogenitor cells Milder forms affect few bones – craniofacial and femur  Maxilla > mandible Clinical –  Painless swelling of jawbones, Facial asymmetry First 2 decades of life Displacement of teeth, malocclusion  Paranasal sinuses, orbits and foramina of the base of the skull can produce – Visual loss, hearing loss, headache, nasal obstruction Radiology – Classic lesions show ground glass appearance  Table 4 Histopath...