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Oral Pathology Short Case 5 - 15-year old Female - Lesion present in anterior maxilla. A mixed radiodense lesion
Oral Pathology Short Case 5 - 15-year old Female - Lesion present in anterior maxilla. A mixed radiodense lesion
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Oral Pathology Short Case 2 - 35 Years Female – Nodular lesion in the floor of the mouth
Answer : Adenoid cystic Carcinoma Salivary gland malignancy slow-growing relentless salivary gland malignancy composed of epithelial and myoepithelial neoplastic cells that form various patterns F : M = 1.5 : 1 4.4 % of all salivary gland tumours Median patient age 57 years Swiss cheese appearance MYB translocation 3 types – Cribriform, Tubular, Solid Perineural and intraneural invasion – 30 % Comedo type necrosis in solid type – ACC – Resembles Basal Cell Ca Grade I, II, III 5 year survival drastic difference but 15-year survival almost equal Histopathology Cribriform Nests of tumour cell interrupted by Sharply punched out spaces filled with basophilic matrix Small Angulated hyperchromatic nuclei Perineural invasion Tubular Bi layered tubules with true lamina Scant cytoplasm Small Angulated hyperchromatic nuclei Solid Sheets of tumour cell Without lumen May consist of epithelial-myoepithelial elements Immunohistochemistry – CD 117 inner epithelial cells, P63, SMA- ...